A Discov. Guanfacine for PTSD nightmares. The military studies will be addressed first. For Permissions, please email: journals.
Science New York, N. Similarly, significant clusters in bilateral amygdalae were found where the difference in response between novel and familiar negative images was significantly greater in men, relative to women, while contrasts comparing novel and familiar neutral or positive images showed no significant differences in the amygdala.
The majority of studies of sex influences on affective processing have used only novel stimuli, potentially confounding the influence of stimulus novelty and valence. Individuals with more persistent amygdala responses also reported greater levels of negative effect.
Thus, the PFC plays a major role in governing human behavior.
In contrast, stress exposure rapidly switches brain orchestration of behavior to primitive circuits, as summarized in Fig. Contrary to the popular belief that women are generally more emotionally reactive than men Birnbaum and Croll, ; Shields, , neuroimaging studies show that these differences are complex and region-specific, such that the direction of sex differences vary in functionally distinct areas of the brain Wager et al.
Human prefrontal lesions increase distractibility to irrelevant sensory inputs. As predicted, women showed a sustained amygdala response to familiar negative items when compared with men.