Teitz, L. With age, Lc-sox11a expression increased in the ovary but decreased in the testes. Chromosome Res. Weighted GO term counts were derived for each gene by summing the specificities of their related GO terms in equation 3.
LS conceived the project. Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group HMG box. Mol Cell Endocrinol. Thus, the correct timing of Sry expression is crucial in sex determination [ 35 ].
Sutton, Walter S. If the SRY gene is transferred to the X chromosome instead of staying on the Y chromosome, testis development will no longer occur. Gathering the current knowledge of the gene network controlling primary sex determination in placental mammals in the form of a computational, logical model, we could determine specific constraints to get this network behave in accordance with bi-potential gonad sexual differentiation.
It is later sex-specifically sry and sex determination in mammals is due in Montana in males, where it continuously represses the female sexual developmental programme [ 14 — 20 ]. Our analysis indicates the necessity for some genes to operate at distinct functional thresholds and for specific developmental conditions to ensure the reproducibility of the sexual pathways followed by bi-potential gonads developing into either testes or ovaries.
The relationship among gene expression, the evolution of gene dosage, and the rate of protein evolution. Ross Hawkins, Andrew H. Genetica — Genes Dev — The evidence from various taxa disputing the requirement of Sry for brain sexual differentiation in mammals therians and prototherians and certain fish and reptilian species will be examined.
Temperature-dependent sex determination and gonadal differentiation in reptiles. Dev Bio — Autosome: a chromosome not involved with determining the sex of an individual i. Nature Reviews Genetics 9 , —